Our proprietary biotechnology platform allows any live cells, tissue, or organoids to be cultured and collected from hydrogel materials without physically or chemically damaging the biological sample.
We develop and manufacture bioinspired materials and devices suitable for isolating tissues or organoids without any attached foreign material (scaffold-free) to create a new approach for ex vivo engineered tissue, organoids, and cell production as therapeutics.
The material is designed to be stable during cell culturing and is provided as a coating in standard cell plates and intended for cells or flat tissue applications. The user can degrade the coating by simply adding a TAG enzyme at any point for collection or passage of the cells or formed tissue.
Corneal Lamellae transplantation (Descemet membrane endothelial keratoplasty DMEK)
Bioengineered Retina transplantation
The material is designed to be cell responsive, allowing cell expansion and remodeling in three dimensions, and is intended for cells, organoids, and tissue applications. The user can degrade the scaffold by simply adding a TAG enzyme at any point for collection or passage of the cells, organoids, or formed tissue.
Capillary network (Angiogenesis)
Mammary gland organoid (mammary epithelial morphogenesis)
For many diseases, tissue and organ transplantation provides the first-line and frequently the only life-saving therapeutic option. However, less than 15% of the global need for tissues and organs is met. For a number of these diseases, only a small portion of the organ needs to be regenerated to restore its function. Over the last decade, cell therapies as regenerative medicine were considered to be the most promising solution to overcome the donor shortage. Nevertheless, despite more than 4000 clinical studies, single cells therapies remain ineffective overall. Cell therapies of "solid tissues" are facing three main issues:
At TissueGUARD, we developed a few solutions which can overcome the above issues. These technologies increase cell viability and prevent their migration from the injected area, thus enabling the therapeutic outcome.
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Neovascularization (Ischemic diseases)
The demand for donor transplants notably exceeds their availability. In the long term, TissueGUARD technology will open up new perspectives for engineering artificially produced tissues to help millions of people worldwide who depend on tissue transplants. TissueGUARD technologies utilizing biomaterial digestion open an entirely new perspective biomaterial applications for living cells, tissues, and organs ex vivo and in vivo.
We are constantly looking for partners in the field of regenerative therapies.